Cesium carbonate → HCID 23720678, compound

HRID 1766939Notes

Reaction equation

HRID 1766939 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]([OH:11])=[O:10])[CH2:4][CH2:3]1.C(=O)([O-])[O-].[Cs+:16].[Cs+]>O>[CH3:1][N:2]1[CH2:3][CH2:4][N:5]([CH2:8][C:9]([O-:11])=[O:10])[CH2:6][CH2:7]1.[Cs+:16]

Participants

4

Reactant 2

HCID 10796Cesium carbonateHCID 2762732(4-Methylpiperazin-1-yl)acetic acid

Product 1

HCID 23720678HCID 23720678, compoundYield 195.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 2-(4-methyl-1-piperazinyl)acetic acid (described in J. Med. Chem., 43, 1493 (2000); 2.5 g, 16 mmol) in water (30 ml) was cooled to 0° C., and cesium carbonate (2.6 g, 7.9 mmol) was added thereto with stirring, then the mixture was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure to give the title compound (4.49 g, 98% yield) as a pale yellow solid.

Workup

  1. stirringthe mixture was stirred at room temperature for 1 hour
  2. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-5b33cebbb59349d98856a432671c3f14
Source dataset
uspto-grants-2007_06
Patent number
US07230023B2

Reaction notes

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