Lawesson's reagent → HCID 22281560, compound

HRID 1766977Notes

Reaction equation

HRID 1766977 reaction equation
[CH2:1]([N:3]1[C:12]2[C:11](=O)[NH:10][CH2:9][C:8]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:7][C:6]=2[C:5]([CH3:22])=[N:4]1)[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:32])=CC=1>C1(C)C=CC=CC=1>[CH2:1]([N:3]1[C:12]2[C:11](=[S:32])[NH:10][CH2:9][C:8]([C:14]3[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=3)=[N:7][C:6]=2[C:5]([CH3:22])=[N:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 9900876HCID 9900876, compound

Product 1

HCID 22281560HCID 22281560, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

(R1=methyl; R2=ethyl; R3=4-methoxyphenyl) 2.2 g (7.4 mmol) of 1-ethyl-5-(4-methoxyphenyl)-3-methyl-6,7-dihydro-1H-pyrazolo[4,3-e][1,4]diazepin-8-one are refluxed in toluene with 6 g (14.8 mmol) of Lawesson's reagent to give 2 g (87%) of an expected compound of type E (see Scheme 1).

Sources & evidence

ORD record
ord-c407af1f9d1546a5962deff32a216a50
Source dataset
uspto-grants-2007_06
Patent number
US07232816B2

Reaction notes

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