Nitric Acid → HCID 178426711, compound

HRID 1766988Notes

Reaction equation

HRID 1766988 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[CH3:11].[N+:12]([O-:15])([OH:14])=[O:13].[N:16]#[C:17][NH2:18]>C(O)C.O>[N+:12]([O-:15])([OH:14])=[O:13].[CH3:11][C:3]1[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=1[NH:1][C:17]([NH2:18])=[NH:16]

Participants

6

Reactant 3

HCID 944Nitric AcidHCID 74442-Methyl-5-NitroanilineHCID 9864Cyanamide

Product 1

HCID 178426711HCID 178426711, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

To a suspension of 10.0 g (0.065 mol) of 2-amino-4-nitrotoluene in ethanol (20 ml) was added 65% nitric acid (4.6 ml, 0.065 mol) dropwise at 0° C. and stirred for 10 minutes. Cyanamide (8.32 g, 0.198 mol) in water (5 ml) was added to the reaction mixture then was refluxed for 25 hours, cooled to 0° C. and filtered and washed with water to yield 2-methyl-5-nitrophenyl-guanidine nitrate.

Workup

  1. temperaturethen was refluxed for 25 hours
  2. filtrationfiltered
  3. washwashed with water

Sources & evidence

ORD record
ord-ffc1bd39709d41449f9b9e31d848dc4c
Source dataset
uspto-grants-2007_06
Patent number
US07232825B2

Reaction notes

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