反应详情

To a stirred solution of the commercially available 4-[(tert-butoxycarbonyl)amino]tetrahydro-2H-pyran-4-carboxylic acid in dioxane, pyridine (0.6 eq.), di-butyl dicarbonate (1.3 eq) and ammonium bicarbonate (1.26 eq) were added and the mixture was stirred at room temperature for 20 hours. Dioxane was concentrated and the residue dissolved in ethyl acetate and washed with HCl 1N, saturated aqueous NaHCO3 solution and brine, dried over Na2SO4, filtered and evaporated in vacuo to obtain the solid compound (C-25).

1. concentrationDioxane was concentrated
2. dissolutionthe residue dissolved in ethyl acetate
3. washwashed with HCl 1N, saturated aqueous NaHCO3 solution and brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated in vacuo
7. customto obtain the solid compound (C-25)