HCID 178499077, compound → HCID 178499078, compound

HRID 1767127Notes

Reaction equation

HRID 1767127 reaction equation
[C:1]([O:9][C:10]1[C:11]([OH:44])=[N:12][C:13]([C:20]2([CH3:43])[CH2:25][N:24]([C:26]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:27])[CH2:23][CH2:22][N:21]2C(OCC2C=CC=CC=2)=O)=[N:14][C:15]=1[C:16]([O:18][CH3:19])=[O:17])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CCOC(C)=O.[Pd]>[C:1]([O:9][C:10]1[C:15]([C:16]([O:18][CH3:19])=[O:17])=[N:14][C:13]([C:20]2([CH3:43])[CH2:25][N:24]([C:26]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:27])[CH2:23][CH2:22][NH:21]2)=[N:12][C:11]=1[OH:44])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 178499077HCID 178499077, compound

Product 1

HCID 178499078HCID 178499078, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 23938PalladiumSolvent

Procedure

1-benzyl 4-tert-butyl 2-[5-(benzoyloxy)-4-hydroxy-6-(methoxycarbonyl)pyrimidin-2-yl]-2-methylpiperazine-1,4-dicarboxylate (C-43) was dissolved in AcOEt and hydrogenated at 1 atm on 10% (w/w) Pd/C over night. After filtration of the catalyst, solvent was evaporated to give the crude title compound (C-44).

Workup

  1. filtrationAfter filtration of the catalyst, solvent
  2. customwas evaporated

Sources & evidence

ORD record
ord-24107b322ac14eb69aff1f2850a3431f
Source dataset
uspto-grants-2007_06
Patent number
US07232819B2

Reaction notes

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