Benzophenone → HCID 12993938, compound

HRID 1767160Notes

Reaction equation

HRID 1767160 reaction equation
C(C1C=CC=CC=1)(=O)C1C=CC=CC=1.C1(C(C2C=CC=CC=2)=[N:22][CH:23]([C:29]2[C:34]([Cl:35])=[CH:33][C:32]([C:36]([F:39])([F:38])[F:37])=[CH:31][N:30]=2)[C:24]([O:26][CH2:27][CH3:28])=[O:25])C=CC=CC=1>>[Cl:35][C:34]1[C:29]([CH:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])[NH2:22])=[N:30][CH:31]=[C:32]([C:36]([F:39])([F:37])[F:38])[CH:33]=1

Participants

3

Reactant 2

HCID 3102BenzophenoneHCID 11704997HCID 11704997, compound

Product 1

HCID 12993938HCID 12993938, compound

Procedure

Two liquid phases were separated. The bottom aqueous phase containing ethyl 2-(3-chloro-5-trifluoromethyl-2-pyridyl)glycinate hydrochloride salt was separated and was ready for the following decarboxylation reaction (preparation of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine hydrochloride). The top organic phase contains all the benzophenone from ethyl N-(diphenylmethylene)-2-(3-chloro-5-trifluoromethyl-2-pyridyl)glycinate and the excess from the BPGI preparation, and was recovered for recycle at step 1. A 93% recovery yield of benzophenone with respect to the 182 g (1 mole) introduced in beinzophenone glycine imine ethyl ester preparation was obtained.

Workup

  1. customTwo liquid phases were separated
  2. additionThe bottom aqueous phase containing ethyl 2-(3-chloro-5-trifluoromethyl-2-pyridyl)glycinate hydrochloride salt
  3. customwas separated
  4. customwas ready for the following decarboxylation reaction (preparation of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine hydrochloride)
  5. customthe excess from the BPGI preparation
  6. customwas recovered for recycle at step 1
  7. additionA 93% recovery yield of benzophenone with respect to the 182 g (1 mole) introduced in beinzophenone glycine imine ethyl ester preparation
  8. customwas obtained

Sources & evidence

ORD record
ord-bc4d8dce7c6b48bfb20a16af99793ca6
Source dataset
uspto-grants-2007_06
Patent number
US07232911B2

Reaction notes

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