Benzophenone → HCID 12993938, compound

Participants

Reaction Steps

Two liquid phases were separated. The bottom aqueous phase containing ethyl 2-(3-chloro-5-trifluoromethyl-2-pyridyl)glycinate hydrochloride salt was separated and was ready for the following decarboxylation reaction (preparation of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine hydrochloride). The top organic phase contains all the benzophenone from ethyl N-(diphenylmethylene)-2-(3-chloro-5-trifluoromethyl-2-pyridyl)glycinate and the excess from the BPGI preparation, and was recovered for recycle at step 1. A 93% recovery yield of benzophenone with respect to the 182 g (1 mole) introduced in beinzophenone glycine imine ethyl ester preparation was obtained.

Provenance & Evidence