反应详情

3-{2-[5-chloro-2-(benzyloxy)-phenyl)cyclopent-1-enyl]-benzoic acid ethyl ester (80 mg) was refluxed for 1 h in methanol/2N sodium hydroxide (10:10 mL). The reaction mixture was then evaporated down to 3 mL. 2N Hydrochloric acid (10 mL) was added and the product extracted with dichloromethane (2×10 mL), dried (magnesium sulphate) and evaporated to give an oil which solidified on standing (70 mg).

1. customThe reaction mixture was then evaporated down to 3 mL
2. addition2N Hydrochloric acid (10 mL) was added
3. extractionthe product extracted with dichloromethane (2×10 mL)
4. dry with materialdried (magnesium sulphate)
5. customevaporated
6. customto give an oil which