3-[2-(2-Benzyloxy-5-chlorophenyl)cyclopent-1-enyl] benzoic acid ethyl ester → 3-(2-(2-(Benzyloxy)-5-chlorophenyl)cyclopent-1-enyl)benzoic acid

Participants

Reaction Steps

3-{2-[5-chloro-2-(benzyloxy)-phenyl)cyclopent-1-enyl]-benzoic acid ethyl ester (80 mg) was refluxed for 1 h in methanol/2N sodium hydroxide (10:10 mL). The reaction mixture was then evaporated down to 3 mL. 2N Hydrochloric acid (10 mL) was added and the product extracted with dichloromethane (2×10 mL), dried (magnesium sulphate) and evaporated to give an oil which solidified on standing (70 mg).

Provenance & Evidence