2-(4-Fluorobenzyloxy)-5-trifluoromethylphenylboronic acid → 6-{2-[5-Trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic Acid Methyl Ester

HRID 1767222Notes

Reaction equation

HRID 1767222 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2Br)[N:6]=1)=[O:4].[F:17][C:18]1[CH:38]=[CH:37][C:21]([CH2:22][O:23][C:24]2[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][C:25]=2B(O)O)=[CH:20][CH:19]=1>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:25]2[CH:26]=[C:27]([C:30]([F:33])([F:31])[F:32])[CH:28]=[CH:29][C:24]=2[O:23][CH2:22][C:21]2[CH:37]=[CH:38][C:18]([F:17])=[CH:19][CH:20]=2)[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 211129212-(4-Fluorobenzyloxy)-5-trifluoromethylphenylboronic acidHCID 695080786-(2-Bromocyclopent-1-enyl)-pyridine-2-carboxylic acid methyl ester

Product 1

HCID 695083316-{2-[5-Trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic Acid Methyl Ester

Procedure

Prepared by general procedure 3 but using 6-(2-bromocyclopent-1-enyl)-pyridine-2-carboxylic acid methyl ester instead of 3-(2-bromocyclopent-1-enyl) -benzoic acid ethyl ester and 2-(4-fluorobenzyloxy)-5-trifluoromethylphenylboronic acid instead of 5-chloro-2-methoxyphenylboronic acid.

Workup

  1. customPrepared by general procedure 3

Sources & evidence

ORD record
ord-2dcd5b9aa80c4c649aef9c39897d46a2
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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