2-(2,4-Difluorobenzyloxy)-5-trifluoromethylphenylboronic acid → 6-{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-pyridine-2-carboxylic Acid Methyl Ester

HRID 1767223노트

반응식

HRID 1767223 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2Br)[N:6]=1)=[O:4].[F:17][C:18]1[CH:38]=[C:37]([F:39])[CH:36]=[CH:35][C:19]=1[CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=1B(O)O>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH2:15][CH2:14][CH2:13][C:12]=2[C:23]2[CH:24]=[C:25]([C:28]([F:30])([F:31])[F:29])[CH:26]=[CH:27][C:22]=2[O:21][CH2:20][C:19]2[CH:35]=[CH:36][C:37]([F:39])=[CH:38][C:18]=2[F:17])[N:6]=1)=[O:4]

참가 물질

3

반응물 2

HCID 211129052-(2,4-Difluorobenzyloxy)-5-trifluoromethylphenylboronic acidHCID 695080786-(2-Bromocyclopent-1-enyl)-pyridine-2-carboxylic acid methyl ester

생성물 1

HCID 695082006-{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-pyridine-2-carboxylic Acid Methyl Ester

실험 절차

Prepared by general procedure 3 but using 6-(2-bromocyclopent-1-enyl) -pyridine-2-carboxylic acid methyl ester instead of 3-(2-bromocyclopent-1-enyl)benzoic acid ethyl ester and 2-(2,4-difluorobenzyloxy)-5-trifluoromethylphenylboronic acid instead of 5-chloro-2-methoxyphenylboronic acid.

후처리

  1. customPrepared by general procedure 3

출처 및 근거

ORD 기록
ord-05620beedcfb47d3b7c114734518fa70
출처 데이터셋
uspto-grants-2007_06
특허 번호
US07232821B2

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