HRID1767228

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6367

Acetyl chloride

C2H3ClO

结构：CCOC(=O)c1cc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccc(F)cc3)CCC2)ccc1N

HCID69507902

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1cc(C2=C(c3cc(C(F)(F)F)ccc3OCc3ccc(F)cc3)CCC2)ccc1NC(C)=O

HCID69507658

未命名化合物

PROCEDURE

实验过程

Prepared by general procedure E but using acetyl chloride instead of propionyl chloride and 3-{2[5-trifluoromethyl-2-(4-fluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid ethyl ester instead of 5-[2-(2-benzyloxy-5-chlorophenyl)-cyclopent-1-enyl]-2-aminobenzoic acid methyl ester.

WORKUP

后处理

customPrepared by general procedure E

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f61c2374576d433ebe9f7a439cc5968e
来源数据集: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07232821B2
来源说明: uspto-grants-2007_06

反应 SMILES

[C:1](Cl)(=[O:3])[CH3:2].[CH2:5]([O:7][C:8](=[O:40])[C:9]1[C:14]([NH2:15])=[CH:13][CH:12]=[C:11]([C:16]2[CH2:20][CH2:19][CH2:18][C:17]=2[C:21]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]=2[O:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][CH:34]=2)[CH:10]=1)[CH3:6]>>[CH2:5]([O:7][C:8](=[O:40])[C:9]1[C:14]([NH:15][C:1](=[O:3])[CH3:2])=[CH:13][CH:12]=[C:11]([C:16]2[CH2:20][CH2:19][CH2:18][C:17]=2[C:21]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]=2[O:31][CH2:32][C:33]2[CH:34]=[CH:35][C:36]([F:39])=[CH:37][CH:38]=2)[CH:10]=1)[CH3:6]