Acetyl chloride → 3-{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-acetamidobenzoic acid ethyl ester

HRID 1767229Notes

Reaction equation

HRID 1767229 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[CH2:5]([O:7][C:8](=[O:41])[C:9]1[C:14]([NH2:15])=[CH:13][CH:12]=[C:11]([C:16]2[CH2:20][CH2:19][CH2:18][C:17]=2[C:21]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]=2[O:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][C:34]=2[F:40])[CH:10]=1)[CH3:6]>>[CH2:5]([O:7][C:8](=[O:41])[C:9]1[C:14]([NH:15][C:1](=[O:3])[CH3:2])=[CH:13][CH:12]=[C:11]([C:16]2[CH2:20][CH2:19][CH2:18][C:17]=2[C:21]2[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[CH:24]=[CH:23][C:22]=2[O:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([F:39])=[CH:35][C:34]=2[F:40])[CH:10]=1)[CH3:6]

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 695076623-{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl)-6-aminobenzoic Acid Ethyl Ester

Product 1

HCID 695077603-{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-acetamidobenzoic acid ethyl ester

Procedure

Prepared by general procedure E but using acetyl chloride instead of propionyl chloride and (3-{2-[5-trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-6-aminobenzoic acid ethyl ester instead of 5-[2-(2-benzyloxy-5-chlorophenyl)-cyclopent-1-enyl]-2-aminobenzoic acid methyl ester.

Workup

  1. customPrepared by general procedure E

Sources & evidence

ORD record
ord-d3bfe7e15ab74297a011eba5c3ac82b5
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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