2-(2,4-Difluorobenzyloxy)-5-bromophenylboronic acid → 3-{2-[5-Bromo-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-aminobenzoic Acid Methyl Ester

HRID 1767231Notes

Reaction equation

HRID 1767231 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]2[CH2:14][CH2:13][CH2:12][C:11]=2Br)[CH:7]=[C:6]([NH2:16])[CH:5]=1.[F:18][C:19]1[CH:36]=[C:35]([F:37])[CH:34]=[CH:33][C:20]=1[CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([Br:29])=[CH:25][C:24]=1B(O)O>>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:5]=[C:6]([NH2:16])[CH:7]=[C:8]([C:10]2[CH2:14][CH2:13][CH2:12][C:11]=2[C:24]2[CH:25]=[C:26]([Br:29])[CH:27]=[CH:28][C:23]=2[O:22][CH2:21][C:20]2[CH:33]=[CH:34][C:35]([F:37])=[CH:36][C:19]=2[F:18])[CH:9]=1

Participants

3

Reactant 2

HCID 211129042-(2,4-Difluorobenzyloxy)-5-bromophenylboronic acidHCID 588876693-Amino-5-(2-bromocyclopent-1-enyl)benzoic acid methyl ester

Product 1

HCID 695078363-{2-[5-Bromo-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-5-aminobenzoic Acid Methyl Ester

Procedure

Prepared by general procedure 3 but using 3-amino-5-(2-bromocyclopent-1-enyl)benzoic acid methyl ester instead of 3-(2-bromocyclopent-1-enyl)benzoic acid ethyl ester and 2-(2,4-difluorobenzyloxy)-5-bromophenylboronic acid instead of 5-chloro-2-methoxyphenylboronic acid.

Workup

  1. customPrepared by general procedure 3

Sources & evidence

ORD record
ord-6f3ad823a1db4898b516db0b82c68e16
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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