2-(2,4-Difluorobenzyloxy)-5-trifluoromethylphenylboronic acid → 2{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-pyridine-4-carboxylic Acid Ethyl Ester

HRID 1767241Notes

Reaction equation

HRID 1767241 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[CH:5][C:6]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])=[C:7](B(O)O)[CH:8]=1.[CH2:24]([O:26][C:27]([C:29]1[CH:34]=[CH:33][N:32]=[C:31]([C:35]2[CH2:39][CH2:38][CH2:37][C:36]=2Br)[CH:30]=1)=[O:28])[CH3:25]>>[CH2:24]([O:26][C:27]([C:29]1[CH:34]=[CH:33][N:32]=[C:31]([C:35]2[CH2:39][CH2:38][CH2:37][C:36]=2[C:7]2[CH:8]=[C:3]([C:2]([F:23])([F:22])[F:1])[CH:4]=[CH:5][C:6]=2[O:12][CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])[CH:30]=1)=[O:28])[CH3:25]

Participants

3

Reactant 2

HCID 211129052-(2,4-Difluorobenzyloxy)-5-trifluoromethylphenylboronic acidHCID 695081572-(Bromocyclopent-1-enyl)pyridine-4-carboxylic acid ethyl ester

Product 1

HCID 695077732{2-[5-Trifluoromethyl-2-(2,4-difluorobenzyloxy)phenyl]cyclopent-1-enyl}-pyridine-4-carboxylic Acid Ethyl Ester

Procedure

Prepared by general procedure B(iii) but using [5-trifluoromethyl-2-(2,4-diflurobenzyloxy)phenyl]boronic acid instead of (5-chloro-2-benzyloxyphenyl)-boronic acid and 2-(bromocyclopent-1-enyl)pyridine-4-carboxylic acid ethyl ester instead of 3-(2-bromo-cyclopent-1-enyl)-6-methyl benzoic acid ethyl ester

Workup

  1. customPrepared by general procedure

Sources & evidence

ORD record
ord-f9a1902317ee49f084ff90304828dff5
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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