2-Benzyloxy-5-trifluoromethylphenylboronic acid → 3-{2-[5-Trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic Acid Ethyl Ester

HRID 1767243Notes

Reaction equation

HRID 1767243 reaction equation
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:4]=[CH:5][C:6]([O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[C:7](B(O)O)[CH:8]=1.[CH2:22]([O:24][C:25](=[O:39])[C:26]1[CH:31]=[C:30]([CH3:32])[CH:29]=[C:28]([C:33]2[CH2:37][CH2:36][CH2:35][C:34]=2Br)[CH:27]=1)[CH3:23]>>[CH2:22]([O:24][C:25](=[O:39])[C:26]1[CH:31]=[C:30]([CH3:32])[CH:29]=[C:28]([C:33]2[CH2:37][CH2:36][CH2:35][C:34]=2[C:7]2[CH:8]=[C:3]([C:2]([F:21])([F:20])[F:1])[CH:4]=[CH:5][C:6]=2[O:12][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:27]=1)[CH3:23]

Participants

3

Reactant 2

HCID 230053392-Benzyloxy-5-trifluoromethylphenylboronic acidHCID 695077393-(2-Bromocyclopent-1-enyl)-5-methylbenzoic acid ethyl ester

Product 1

HCID 695081363-{2-[5-Trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}-5-methylbenzoic Acid Ethyl Ester

Procedure

Prepared by general procedure B(iii) but using [5-trifluoromethyl-2-(benzyloxy)phenyl]boronic acid instead of (5-chloro-2-benzyloxyphenyl)boronic acid and 3-(2-bromocyclopent-1-enyl)-5-methylbenzoic acid ethyl ester instead of 3-(2-bromocyclopent-1-enyl)-6-methylbenzoic acid ethyl ester.

Workup

  1. customPrepared by general procedure

Sources & evidence

ORD record
ord-ab88f722d0f2454f93ad789839a31827
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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