5-Fluoro-2-methoxyphenylboronic acid → 6-{2-[5-Fluoro-2-(methoxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic Acid Ethyl Ester

HRID 1767244Notes

Reaction equation

HRID 1767244 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][CH3:12])=[C:6](B(O)O)[CH:7]=1.[CH2:13]([O:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]2[CH2:28][CH2:27][CH2:26][C:25]=2Br)[N:19]=1)=[O:17])[CH3:14]>>[CH2:13]([O:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]2[CH2:28][CH2:27][CH2:26][C:25]=2[C:6]2[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=2[O:11][CH3:12])[N:19]=1)=[O:17])[CH3:14]

Participants

3

Reactant 2

HCID 27826735-Fluoro-2-methoxyphenylboronic acidHCID 578624336-(2-Bromocyclopent-1-enyl)-pyridine-2-carboxylic acid ethyl ester

Product 1

HCID 695080186-{2-[5-Fluoro-2-(methoxy)phenyl]cyclopent-1-enyl}pyridine-2-carboxylic Acid Ethyl Ester

Procedure

Prepared by general procedure B(iii) but using 5-fluoro-2-methoxyphenylboronic acid instead of (5-chloro-2-benzyloxyphenyl)boronic acid and 6-(2-bromocyclopent-1-enyl)-pyridine-2-carboxylic acid ethyl ester instead of 3-(2-bromocyclopent-1-enyl)-6-methylbenzoic acid ethyl ester.

Workup

  1. customPrepared by general procedure

Sources & evidence

ORD record
ord-33dfe235e2244ad184a51aac7c30d752
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

Loading…