m-Chloroperbenzoic acid → HCID 69508187, compound

HRID 1767261Notes

Reaction equation

HRID 1767261 reaction equation
ClC1C=CC=C(C(OO)=[O:9])C=1.[F:12][C:13]([C:16]1[C:17]([O:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[C:18]([C:22]2[CH2:26][CH2:25][CH2:24][C:23]=2[C:27]2[CH:28]=[N:29][CH:30]=[C:31]([CH:35]=2)[C:32]([OH:34])=[O:33])[CH:19]=[CH:20][CH:21]=1)([F:15])[F:14]>O1CCOCC1>[F:12][C:13]([C:16]1[C:17]([O:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[C:18]([C:22]2[CH2:26][CH2:25][CH2:24][C:23]=2[C:27]2[CH:28]=[N+:29]([O-:9])[CH:30]=[C:31]([CH:35]=2)[C:32]([OH:34])=[O:33])[CH:19]=[CH:20][CH:21]=1)([F:15])[F:14]

Participants

4

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 21112866HCID 21112866, compound

Product 1

HCID 69508187HCID 69508187, compoundYield 18%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

3-Chloroperbenzoic acid (25 mg, 0.11 mmol) was added to a solution of 5-{2-[trifluoromethyl-2-(benzyloxy)phenyl]cyclopent-1-enyl}nicotinic acid (44 mg, 0.1 mmol) in dioxan (2 ml) and left overnight at room temperature. The resulting mixture was evaporated to dryness and purified by preparative mass directed chromatography to give the title compound as an off-white solid (8 mg, 18%).

Workup

  1. customThe resulting mixture was evaporated to dryness
  2. custompurified by preparative mass

Sources & evidence

ORD record
ord-5d55bdaa1b30485ab0c0a0520eaf22f6
Source dataset
uspto-grants-2007_06
Patent number
US07232821B2

Reaction notes

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