Acetazolamide → 5-Amino-1,3,4-thiadiazole-2-sulfonamide

HRID 1767275Notes

Reaction equation

HRID 1767275 reaction equation
CC([NH:4][C:5]1[S:9][C:8]([S:10]([NH2:13])(=[O:12])=[O:11])=[N:7][N:6]=1)=O>Cl>[NH2:4][C:5]1[S:9][C:8]([S:10]([NH2:13])(=[O:12])=[O:11])=[N:7][N:6]=1

Participants

3

Reactant 1

HCID 1986Acetazolamide

Product 1

HCID 847245-Amino-1,3,4-thiadiazole-2-sulfonamide

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
60 °C

Procedure

22.2 gr of acetazolamide, was dissolved in 100 ml concentrated HCl solution (35%) and refluxed on a water bath (60° C.) for two hours.

Sources & evidence

ORD record
ord-94f18e4a24214a36999685e180539de9
Source dataset
uspto-grants-2007_06
Patent number
US07232929B2

Reaction notes

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