反应详情

Compound A14 was prepared via the di-Boc-compound from 5-cyclopropyl-meth-oxy-2-nitro-4-trifluoromethyl-phenylamine [prepared by stirring commercially available 5-chloro-2-nitro-4-trifluoromethyl-phenylamine [CAS-No. 35375-74-7], (hydroxy-methyl)cyclopropane and KOH in DMSO at 23° C. for 4 days and at 60° C. for 7 days] (4.49 g, 16.3 mmol) and Boc20 (7.45 g, 34.1 mmol), followed by treatment with 2 eq. TFA in CH2Cl2 according to the general procedure A (method c).

1. customprepared