Piperazine → HCID 178505183, compound

HRID 1767643Notes

Reaction equation

HRID 1767643 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH3:7][S:8]([Cl:11])(=[O:10])=[O:9]>C(Cl)Cl>[Cl-:11].[S:8]([NH+:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)([CH3:7])(=[O:10])=[O:9]

Participants

4

Reactant 2

HCID 4837PiperazineHCID 31297Methanesulfonyl chloride

Product 1

HCID 178505183HCID 178505183, compoundYield 32%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Procedure

To a stirred solution of piperazine (4.3 g; 50 mmol) in CH2Cl2 (50 ml) at +5 C. was added a solution of CH3SO2Cl (4.25 ml; 55 mmol) in CH2Cl2 (15 ml). The thick reaction mixture was stirred at rt. for 12 h, added CH2Cl2 (100 ml), and extracted with 1 M HCl (300 ml). A precipitate formed in the aqueous phase was filtered of to give 2.66 g of N-mesylpiperazinium chloride (32%).

Workup

  1. extractionextracted with 1 M HCl (300 ml)
  2. customA precipitate formed in the aqueous phase
  3. filtrationwas filtered of

Sources & evidence

ORD record
ord-939b45eae6bc49b9ae3673fc02fecf4f
Source dataset
uspto-grants-2007_06
Patent number
US07235548B2

Reaction notes

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