Aluminium lithium hydride → HCID 22324019, compound

HRID 1767653Notes

Reaction equation

HRID 1767653 reaction equation
[N+:1]([C:4]1[CH:18]=[CH:17][C:7]2[N:8]3[CH2:16][CH2:15][CH2:14][CH:9]3[NH:10][S:11](=[O:13])(=[O:12])[C:6]=2[CH:5]=1)([O-])=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[NH2:1][C:4]1[CH:18]=[CH:17][C:7]2[N:8]3[CH2:16][CH2:15][CH2:14][C:9]3=[N:10][S:11](=[O:13])(=[O:12])[C:6]=2[CH:5]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 22324001HCID 22324001, compound

Product 1

HCID 22324019HCID 22324019, compoundYield 105.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A stirred solution of 7-nitro-1,2,3,3a,4,5-hexahydrobenzo[e]pyrrolo[2,1-c]-1,2,4-thiadiazine-5,5-dioxide (167 mg; 0.6 mmol) in dry THF (2 ml) at −50° C. was added LiAlH4 (115 mg; 3 mmol) in one portion. The reaction mixture was allowed to warm up to rt. and stirred over night. The reaction mixture was quenched by addition of H2O and 10 M NaOH, stirred, filtered through celite and evaporated to dryness to give 150 mg product.

Workup

  1. customThe reaction mixture was quenched by addition of H2O and 10 M NaOH
  2. stirringstirred
  3. filtrationfiltered through celite
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-5f9acda172fc4ce6b67ce060fd36b4e6
Source dataset
uspto-grants-2007_06
Patent number
US07235548B2

Reaction notes

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