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HRID1767878

反应详情

EQUATION

反应方程式

HRID 1767878 的结构方程式

REACTANTS

反应物

3
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：CC(Br)C(=O)OC(C)(C)C
HCID545327

tert-Butyl 2-bromopropanoate

C7H13BrO2

结构：Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1cccc2[nH]ccc12
HCID11574605

1H-Indole, 4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]-

C20H15F3N2OS

PRODUCTS

生成物

1
结构：Cc1nc(-c2ccc(C(F)(F)F)cc2)sc1COc1cccc2c1ccn2C(C)C(=O)OC(C)(C)C
HCID69283091

未命名化合物

PROCEDURE

实验过程

In analogy to the procedure described in example 1 b], 4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-1H-indole (example 1 a]) was reacted with 2-bromo-propionic acid tert-butyl ester in the presence of sodium hydride to obtain [rac]-2-{4-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-propionic acid tert-butyl ester as yellow oil.