反应详情

温度

100 °C

A mixture of [4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-acetonitrile (8.86 g, 31 mmol), sodium hydroxide (12.5 g, 314 mmol), water (160 ml) and ethanol (160 ml) was stirred vigorously at 100° C. for 2.5 h. The reaction mixture was poured onto crushed ice and aqueous HCl and extracted three times with dichloromethane. The combined extracts were washed with water and brine, and dried over anhydrous sodium sulfate. Evaporation of the solvent under reduced pressure gave 9.5 g (quant.) of the title compound as light yellow solid.

1. additionThe reaction mixture was poured
2. extractionextracted three times with dichloromethane
3. washThe combined extracts were washed with water and brine
4. dry with materialdried over anhydrous sodium sulfate
5. customEvaporation of the solvent under reduced pressure