Sodium Hydroxide → {6-[2-(4-Trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid

HRID 1767888Notes

Reaction equation

HRID 1767888 reaction equation
C([O:5][C:6](=[O:34])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[S:23][C:22]([C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=4)=[N:21][CH:20]=3)[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[OH-].[Na+]>>[F:33][C:30]([F:31])([F:32])[C:27]1[CH:28]=[CH:29][C:24]([C:22]2[S:23][C:19]([CH2:18][O:17][C:14]3[CH:15]=[C:16]4[C:11]([CH:10]=[CH:9][N:8]4[CH2:7][C:6]([OH:34])=[O:5])=[CH:12][CH:13]=3)=[CH:20][N:21]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69279690{6-[2-(4-Trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester

Product 1

HCID 11441840{6-[2-(4-Trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described in example 2 c], {6-[2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with NaOH to obtain {6-[2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid as orange solid.

Sources & evidence

ORD record
ord-0cfeccc1263440bca4890dc614e913f2
Source dataset
uspto-grants-2007_06
Patent number
US07235572B2

Reaction notes

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