Lithium Hydroxide → [6-(5-methyl-2-phenyl-thiazol-4-ylmethoxy)-indol-1-yl]-acetic acid

HRID 1767905Notes

Reaction equation

C([O:5][C:6](=[O:31])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[N:20]=[C:21]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)[S:22][C:23]=3[CH3:24])[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[CH3:24][C:23]1[S:22][C:21]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[N:20][C:19]=1[CH2:18][O:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][N:8]2[CH2:7][C:6]([OH:31])=[O:5])=[CH:12][CH:13]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69280208HCID 69280208, compound

Product 1

HCID 11211136[6-(5-methyl-2-phenyl-thiazol-4-ylmethoxy)-indol-1-yl]-acetic acid

Procedure

In analogy to the procedure described in example 2 c], [6-(5-methyl-2-phenyl-thiazol-4-ylmethoxy)-indol-1-yl]-acetic acid tert-butyl ester was treated with LiOH to obtain [6-(5-methyl-2-phenyl-thiazol-4-ylmethoxy)-indol-1-yl]-acetic acid as light yellow foam.

Sources & evidence

ORD record: ord-f064ff81bd5c4e2ca40345bd9d22756f
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235572B2

Reaction notes

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