Lithium Hydroxide → HCID 11374583, compound

HRID 1767911Notes

Reaction equation

C([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH:16]([C:18]3[S:22][C:21]([C:23]4[CH:28]=[CH:27][C:26]([C:29]([F:32])([F:31])[F:30])=[CH:25][CH:24]=4)=[N:20][C:19]=3[CH3:33])[CH3:17])=[CH:12][CH:13]=2)[CH:8]=[CH:7]1)C.[Li+].[OH-]>>[CH3:33][C:19]1[N:20]=[C:21]([C:23]2[CH:28]=[CH:27][C:26]([C:29]([F:31])([F:32])[F:30])=[CH:25][CH:24]=2)[S:22][C:18]=1[CH:16]([O:15][C:11]1[CH:10]=[C:9]2[C:14](=[CH:13][CH:12]=1)[N:6]([CH2:5][C:4]([OH:34])=[O:3])[CH:7]=[CH:8]2)[CH3:17]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69280203HCID 69280203, compound

Product 1

HCID 11374583HCID 11374583, compound

Procedure

In analogy to the procedure described in example 2 c], [rac]-(5-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid ethyl ester was treated with LiOH to obtain [rac]-(5-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid as yellow solid.

Sources & evidence

ORD record: ord-15a07e2d9e854d319d9897b7fae38070
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235572B2

Reaction notes

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