Lithium Hydroxide → (3-Chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid

HRID 1767921Notes

Reaction equation

HRID 1767921 reaction equation
C([O:5][C:6](=[O:37])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][CH2:19][C:20]3[S:24][C:23]([C:25]4[CH:30]=[CH:29][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:27][CH:26]=4)=[N:22][C:21]=3[CH3:35])[CH:15]=2)[C:10]([Cl:36])=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[Cl:36][C:10]1[C:11]2[C:16](=[CH:15][C:14]([O:17][CH2:18][CH2:19][C:20]3[S:24][C:23]([C:25]4[CH:26]=[CH:27][C:28]([C:31]([F:34])([F:33])[F:32])=[CH:29][CH:30]=4)=[N:22][C:21]=3[CH3:35])=[CH:13][CH:12]=2)[N:8]([CH2:7][C:6]([OH:37])=[O:5])[CH:9]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 69279677(3-Chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester

Product 1

HCID 11214104(3-Chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid

Procedure

In analogy to the procedure described in example 2 c], (3-chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester was treated with LiOH to obtain (3-chloro-6-{2-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid as light yellow solid.

Sources & evidence

ORD record
ord-5001d8b5380c4decb06e92432c6d45cc
Source dataset
uspto-grants-2007_06
Patent number
US07235572B2

Reaction notes

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