Lithium Hydroxide → HCID 23614516, compound

HRID 1767924Notes

Reaction equation

C([O:5][C:6](=[O:43])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH:18]([C:27]3[S:31][C:30]([C:32]4[CH:37]=[CH:36][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:34][CH:33]=4)=[N:29][C:28]=3[CH3:42])[CH2:19][CH2:20][CH:21]3[O:26][CH2:25][CH2:24][CH2:23][O:22]3)[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[O:26]1[CH2:25][CH2:24][CH2:23][O:22][CH:21]1[CH2:20][CH2:19][CH:18]([C:27]1[S:31][C:30]([C:32]2[CH:33]=[CH:34][C:35]([C:38]([F:41])([F:40])[F:39])=[CH:36][CH:37]=2)=[N:29][C:28]=1[CH3:42])[O:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][N:8]2[CH2:7][C:6]([OH:43])=[O:5])=[CH:12][CH:13]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69279674HCID 69279674, compound

Product 1

HCID 23614516HCID 23614516, compound

Procedure

In analogy to the procedure described in example 2 c], [rac]-(6-{3-[1,3]dioxan-2-yl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-indol-1-yl)-acetic acid tert-butyl ester was treated with LiOH to obtain [rac]-(6-{3-[1,3]dioxan-2-yl-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-propoxy}-indol-1-yl)-acetic acid as yellow oil.

Sources & evidence

ORD record: ord-9829e69948d34c0c952e7208d2c2de97
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235572B2

Reaction notes

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