Aluminium lithium hydride → {2-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methanol

HRID 1767971Notes

Reaction equation

HRID 1767971 reaction equation
C([O:3][C:4]([C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[C:13]([F:21])[C:12]=2[F:22])=[N:8][C:7]=1[CH3:23])=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[F:22][C:12]1[C:13]([F:21])=[C:14]([C:17]([F:20])([F:18])[F:19])[CH:15]=[CH:16][C:11]=1[C:9]1[S:10][C:6]([CH2:4][OH:3])=[C:7]([CH3:23])[N:8]=1

Participants

3

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 69280529HCID 69280529, compound

Product 1

HCID 23614483{2-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methanol

Procedure

In analogy to the procedure described for example 8 c], 2-(2,3-difluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazole-5-carboxylic acid ethyl ester was reduced with lithium aluminum hydride to give [2-(2,3-difluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-yl]-methanol as white solid.

Sources & evidence

ORD record
ord-1d7a0246a94a403c833d9aaccef829f2
Source dataset
uspto-grants-2007_06
Patent number
US07235572B2

Reaction notes

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