Lithium Hydroxide → HCID 23614507, compound

HRID 1767974Notes

Reaction equation

C([O:5][C:6](=[O:37])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[S:23][C:22]([C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[C:26]([F:34])[C:25]=4[F:35])=[N:21][C:20]=3[CH3:36])[CH:15]=2)[CH:10]=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[F:35][C:25]1[C:26]([F:34])=[C:27]([C:30]([F:32])([F:31])[F:33])[CH:28]=[CH:29][C:24]=1[C:22]1[S:23][C:19]([CH2:18][O:17][C:14]2[CH:15]=[C:16]3[C:11]([CH:10]=[CH:9][N:8]3[CH2:7][C:6]([OH:37])=[O:5])=[CH:12][CH:13]=2)=[C:20]([CH3:36])[N:21]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69280386HCID 69280386, compound

Product 1

HCID 23614507HCID 23614507, compound

Procedure

In analogy to the procedure described in example 2 c], {6-[2-(2,3-difluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {6-[2-(2,3-difluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid as yellow solid.

Sources & evidence

ORD record: ord-b2f018ceae2849f194819265ade4f36a
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235572B2

Reaction notes

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