Lithium Hydroxide → HCID 10127665, compound

HRID 1767975Notes

Reaction equation

C([O:3][C:4](=[O:34])[CH2:5][N:6]1[C:14]2[C:9](=[CH:10][C:11]([O:15][CH2:16][C:17]3[S:21][C:20]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=4)=[N:19][C:18]=3[CH3:32])=[CH:12][CH:13]=2)[CH:8]=[C:7]1[CH3:33])C.[Li+].[OH-]>>[CH3:33][C:7]1[N:6]([CH2:5][C:4]([OH:34])=[O:3])[C:14]2[C:9]([CH:8]=1)=[CH:10][C:11]([O:15][CH2:16][C:17]1[S:21][C:20]([C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:29])[F:30])=[CH:26][CH:27]=3)=[N:19][C:18]=1[CH3:32])=[CH:12][CH:13]=2

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69283058HCID 69283058, compound

Product 1

HCID 10127665HCID 10127665, compound

Procedure

In analogy to the procedure described in example 2 c], {2-methyl-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid ethyl ester was treated with LiOH to obtain {2-methyl-5-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid as off-white powder.

Sources & evidence

ORD record: ord-8bf277f5e3a94fed8d7467065eea4f05
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235572B2

Reaction notes

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