Lithium Hydroxide → {3-Chloro-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid

HRID 1767982Notes

Reaction equation

C([O:5][C:6](=[O:36])[CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH2:18][C:19]3[S:23][C:22]([C:24]4[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=4)=[N:21][C:20]=3[CH3:34])[CH:15]=2)[C:10]([Cl:35])=[CH:9]1)(C)(C)C.[Li+].[OH-]>>[Cl:35][C:10]1[C:11]2[C:16](=[CH:15][C:14]([O:17][CH2:18][C:19]3[S:23][C:22]([C:24]4[CH:25]=[CH:26][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:28][CH:29]=4)=[N:21][C:20]=3[CH3:34])=[CH:13][CH:12]=2)[N:8]([CH2:7][C:6]([OH:36])=[O:5])[CH:9]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 69280392{3-Chloro-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester

Product 1

HCID 23614493{3-Chloro-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid

Procedure

In analogy to the procedure described in example 2 c], {3-chloro-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid tert-butyl ester was treated with LiOH to obtain {3-chloro-6-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-indol-1-yl}-acetic acid as off-white solid.

Sources & evidence

ORD record: ord-990f9062cba442069a2c263383644537
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235572B2

Reaction notes

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