HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyldimethylsilyl chloride → 3-bromo-1-(tert-butyl-dimethyl-silanyl)-6-(tert-butyl-dimethyl-silanyloxy)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6-((tert-butyldimethylsilyl)oxy)-1H-indole | HCID 22250816 | — |
| Product | 3-bromo-1-(tert-butyl-dimethyl-silanyl)-6-(tert-butyl-dimethyl-silanyloxy)-1H-indole | HCID 23614490 | — |
Reaction Steps
In analogy to the procedure described in example 27 b], 6-(tert-butyl-dimethyl-silanyloxy)-1H-indole was reacted with tert-butyldimethylsilyl chloride and subsequently with N-bromosuccinimide to obtain 3-bromo-1-(tert-butyl-dimethyl-silanyl)-6-(tert-butyl-dimethyl-silanyloxy)-1H-indole as brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07235572B2 |
| Source dataset | uspto-grants-2007_06 |
| ORD ID | ord-720d8c1f05074d618f4b217a3bb19e6c |
| Source note | uspto-grants-2007_06 |