反应详情

To a stirred suspension of LiAlH4 (200 mg, excess) in THF at 0° C., naphtho[1,2-b]furan-3-yl-acetic acid ethyl ester (1.27 g, 5 mmol) in THF (20 mL) was added slowly. After the addition, reaction mixture was stirred at room temperature for 1 hr and quenched with saturated NH4Cl solution. The product was extracted with chloroform and washed well with water. It was dried over anhydrous MgSO4; filtered and concentrated. The product, 2-naphtho[1,2-b]furan-3-yl ethanol, was obtained as white oil, was pure enough and taken to the next step without purification. Yield: 900 mg (84%); 213 (M+H).

1. additionAfter the addition, reaction mixture
2. customquenched with saturated NH4Cl solution
3. extractionThe product was extracted with chloroform
4. washwashed well with water
5. dry with materialIt was dried over anhydrous MgSO4
6. filtrationfiltered
7. concentrationconcentrated