反应详情

温度

0 °C

1.90 g (8.25 mmol) 1-[4-(4-methoxy-phenyl)-butyl]-1H-imidazole and 28 ml (247 mmol) 48% aqueous hydrobromic acid were stirred at 80° C. for 10 h. The mixture was cooled to 0° C., 23 ml of 4 N NaOH added, extracted with toluene and the aqueous phase adjusted to pH=6.3 by addition of 6 N HCl. The resulting precipitate was isolated, washed with ethyl acetate/n-heptane 2:1 and dried. 1.2 g (67%) slightly yellow powder.

1. extractionextracted with toluene
2. additionthe aqueous phase adjusted to pH=6.3 by addition of 6 N HCl
3. customThe resulting precipitate was isolated
4. washwashed with ethyl acetate/n-heptane 2:1
5. customdried