反应详情

A mixture of 3.20 g (12.3 mmol) [6-(4-methoxy-phenyl)-hex-1-ynyl]-trimethyl-silane, 50 ml methanol and 12.3 ml (24.6 mmol) 2N NaOH was stirred for 2 h at r.t. After neutralization with 13 ml 2N HCl methanol was distilled off and the aqueous phase extracted with diethyl ether. Drying (Na2SO4) and removal of solvents in vacuo gave 1.80 g (78%) of the title compound.

1. distillationAfter neutralization with 13 ml 2N HCl methanol was distilled off
2. extractionthe aqueous phase extracted with diethyl ether
3. customDrying
4. custom(Na2SO4) and removal of solvents in vacuo