Sodium Hydroxide → 1-Hex-5-ynyl-4-methoxy-benzene

Participants

Reaction Steps

A mixture of 3.20 g (12.3 mmol) [6-(4-methoxy-phenyl)-hex-1-ynyl]-trimethyl-silane, 50 ml methanol and 12.3 ml (24.6 mmol) 2N NaOH was stirred for 2 h at r.t. After neutralization with 13 ml 2N HCl methanol was distilled off and the aqueous phase extracted with diethyl ether. Drying (Na2SO4) and removal of solvents in vacuo gave 1.80 g (78%) of the title compound.

Provenance & Evidence