Formic Acid → HCID 178506436, compound

HRID 1768055Notes

Reaction equation

[F:1][S:2]([F:55])([F:54])([F:53])([F:52])[C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]2[O:12][CH:13]=[C:14]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][C:28]4[N:29]=[N:30][N:31](C(C5C=CC=CC=5)(C5C=CC=CC=5)C5C=CC=CC=5)[CH:32]=4)=[CH:20][CH:19]=3)[N:15]=2)=[CH:5][CH:4]=1.C(O)=O.O>O1CCCC1>[F:55][S:2]([F:1])([F:52])([F:53])([F:54])[C:3]1[CH:4]=[CH:5][C:6](/[CH:9]=[CH:10]/[C:11]2[O:12][CH:13]=[C:14]([CH2:16][O:17][C:18]3[CH:19]=[CH:20][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][C:28]4[N:29]=[N:30][NH:31][CH:32]=4)=[CH:22][CH:23]=3)[N:15]=2)=[CH:7][CH:8]=1

Participants

Conditions

Temperature: 60 °C

Procedure

A mixture of 98 mg 4-[4-(4-{2-[(E)-2-(-4-pentafluorosulfanyl-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butyl]-1-trityl-1H-[1,2,3]triazole, 100 μl formic acid, 10 μl water and 1.0 ml tetrahydrofuran was stirred at 60° C. for 21 h. After removal of solvents in vacuo 4-[4-(4-{2-[(E)-2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butyl]-1H-[1,2,3]triazole was obtained by HPLC-MS-purification.

Workup

customAfter removal of solvents in vacuo 4-[4-(4-{2-[(E)-2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butyl]-1H-[1,2,3]triazole
customwas obtained by HPLC-MS-purification

Sources & evidence

ORD record: ord-3d7208f42cd84b28b582d89fb4b63856
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235574B2

Reaction notes

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