反应详情

14 mg (0.50 mmol) 95% sodium hydride were given to a solution of 110 mg (0.50 mmol) 4-(2-[1,2,3]Triazol-1-yl-ethoxymethyl)-phenol in 4.0 ml DMF and stirred for 15 min. 173 mg (0.50 mmol) 4-chloromethyl-2-[2-(4-pentafluorosulfanyl-phenyl)-vinyl]-oxazole were added and stirring continued at r.t. overnight. After addition of 10 ml water the resulting precipitate was washed twice with 10 ml water, 2×10 ml methanol, diethyl ether and dried at 45° C. in vacuum. Yield 155 mg (59%) colorless powder.

1. stirringstirring
2. waitcontinued at r.t. overnight
3. washwas washed twice with 10 ml water, 2×10 ml methanol, diethyl ether
4. customdried at 45° C. in vacuum