Potassium Iodide → HCID 23614537, compound

1H-[1,2,3]Triazole (10.36 g, 0.15 mol), sodium hydroxide (6 g, 0.15 mol) and potassium iodide (2.49 g, 0.015 mol) were dissolved in 2-methyl-2-butanol (50 ml) and heated to reflux for 1 h. At this temperature 4-bromo-but-1-ene (20.25 g, 0.15 mol) in 2-methyl-2-butanol (20 ml) were added dropwise and the resulting mixture was heated at reflux temperature for 4 h. After removal of the solvent the residue was taken up in ethyl acetate (100 ml), washed with water (3×50 ml), dried over sodium sulfate and concentrated. The crude product was purified by destillation yielding 0.65 g 2-but-3-enyl-2H-[1,2,3]triazole (b.p. 90-100° C. at 10 mbar), 1H-NMR (400 MHz, [D6]-DMSO): δ=2.62 (q, 2H, CH2—CH═CH2), 4.48 (t, 2H, CH2-triazole), 4.97–5.06 (m, 2H, CH2—CH═CH2), 5.75 (m, 1H, CH2—CH═CH2), 7.75 (s, 2H, triazole) and 6.36 g (34%) 1-but-3-enyl-1H-[1,2,3]triazole (b.p. 106–108° C. at 10 mbar) as a colorless liquid.

1. temperatureheated
2. temperatureto reflux for 1 h
3. temperaturethe resulting mixture was heated
4. temperatureat reflux temperature for 4 h
5. customAfter removal of the solvent the residue
6. washwashed with water (3×50 ml)
7. dry with materialdried over sodium sulfate
8. concentrationconcentrated
9. customThe crude product was purified by destillation

ORD record

ord-a25bb8bb374b4019bfe292b9f0ab1337

Source dataset

uspto-grants-2007_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07235574B2