Diethyl Ether → HCID 23614751, compound

HRID 1768136Notes

Reaction equation

HRID 1768136 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=1.CC1(C)[O:25][C:24](=O)[C:21]2([CH2:23][CH2:22]2)[C:20](=[O:27])[O:19]1.C(OCC)C>ClCCl>[F:1][C:2]1[CH:3]=[C:4]([CH:14]=[CH:15][CH:16]=1)[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:23][CH2:22][CH:21]([C:20]([OH:27])=[O:19])[C:24]2=[O:25])=[CH:9][CH:8]=1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 797206,6-Dimethyl-5,7-dioxaspiro(2.5)octane-4,8-dioneHCID 167753144-(3-Fluoro-benzyloxy)-phenylamine

Product 1

HCID 23614751HCID 23614751, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 561 mg (2.6 mmol) 4-(3-fluoro-benzyloxy)-phenylamine and 448 mg (2.6 mmol) 6,6-dimethyl-5,7-dioxa-spiro[2,5]octane-4,8-dione in 2 ml dichloromethane is refluxed for 16 hours. 5 ml of diethylether is added and the precipitate filtered off to yield 485 mg (57%) of a colorless solid. MS: m/e=330.2 (M+H)+.

Workup

  1. filtrationthe precipitate filtered off

Sources & evidence

ORD record
ord-887ca0e0f2cb43fbbd4fb69c4c39d088
Source dataset
uspto-grants-2007_06
Patent number
US07235581B2

Reaction notes

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