Methylamine → HCID 10246763, compound

HRID 1768140Notes

Reaction equation

HRID 1768140 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][O:7][C:8]2[CH:13]=[CH:12][C:11]([N:14]3[CH2:18][CH2:17][CH:16]([C:19](O)=[O:20])[C:15]3=[O:22])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[CH3:25][NH2:26]>>[CH3:25][NH:26][C:19]([CH:16]1[CH2:17][CH2:18][N:14]([C:11]2[CH:12]=[CH:13][C:8]([O:7][CH2:6][C:5]3[CH:23]=[CH:24][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:9][CH:10]=2)[C:15]1=[O:22])=[O:20]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 23614752HCID 23614752, compound

Product 1

HCID 10246763HCID 10246763, compound

Procedure

The title compound is prepared in analogy to Example 3d) from (RS)-1-[4-(4-fluoro-benzyloxy)-phenyl]-2-oxo-pyrrolidine-3-carboxylic acid and methylamine. Yield: 17% of a colorless solid. MS: m/e=343.2 (M+H)+.

Sources & evidence

ORD record
ord-27d8971daef94253b40b5bb7dd4550b7
Source dataset
uspto-grants-2007_06
Patent number
US07235581B2

Reaction notes

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