Potassium Carbonate → HCID 69490896, compound

HRID 1768154Notes

Reaction equation

[C:1]([O:5][C:6](=[O:21])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=2)[C:9]1=[O:20])([CH3:4])([CH3:3])[CH3:2].[F:22][C:23]1[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[C:24]=1[CH2:25]Br.C(=O)([O-])[O-].[K+].[K+]>>[C:1]([O:5][C:6](=[O:21])[NH:7][C@H:8]1[CH2:12][CH2:11][N:10]([C:13]2[CH:14]=[CH:15][C:16]([O:19][CH2:25][C:24]3[C:23]([F:22])=[CH:30][CH:29]=[CH:28][C:27]=3[F:31])=[CH:17][CH:18]=2)[C:9]1=[O:20])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 5814352-(Bromomethyl)-1,3-difluorobenzene

HCID 69490626HCID 69490626, compound

Product 1

HCID 69490896HCID 69490896, compound

Procedure

In an analogous manner to that described in Example 2c), the alkylation of the (S)-[1-(4-hydroxy-phenyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester [Example 16 a)] with 2,6-difluorobenzylbromide in presence of potassium carbonate yields the title compound as a white solid; MS: m/e=419 (M+H)+.

Sources & evidence

ORD record: ord-0f8883a793b14be4880d3452c214becb
Source dataset: uspto-grants-2007_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07235581B2

Reaction notes

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