Hydrochloric Acid → 7-Piperidin-4-yl-7,9-dihydro-8H-purin-8-one hydrochloride

HRID 1768176Notes

Reaction equation

HRID 1768176 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[N:18][CH:19]=[N:20][CH:21]=3)[NH:16][C:15]2=[O:23])[CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:24]>O1CCOCC1>[ClH:24].[NH:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:22]3[C:17](=[N:18][CH:19]=[N:20][CH:21]=3)[NH:16][C:15]2=[O:23])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 222932617-(1-benzylpiperidin-4-yl)-7,9-dihydro-8H-purin-8-one

Product 1

HCID 222931977-Piperidin-4-yl-7,9-dihydro-8H-purin-8-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 7-(1-benzylpiperidin-4-yl)-7,9-dihydro-8H-purin-8-one (1.2 g, 3.7 mmol) in 4N hydrogen chloride in dioxane (50 mL), was stirred vigorously at room temperature for 3 h. The reaction was concentrated in vacuo to give the title compound as a white solid. MS 220 (M+1)

Workup

  1. concentrationThe reaction was concentrated in vacuo

Sources & evidence

ORD record
ord-297ffafdd50e4420aaf042c0d1cbb756
Source dataset
uspto-grants-2007_06
Patent number
US07235545B2

Reaction notes

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