benzyl 4-(6-oxo-6,7-dihydro-5H-imidazo[4,5-c]pyridazin-5-yl)piperidine-1-carboxylate → 5-Piperidin-4-yl-5,7-dihydro-6H-imidazo[4,5-c]pyridazin-6-one

HRID 1768180Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1768180
[O:1]=[C:2]1[NH:10][C:5]2[N:6]=[N:7][CH:8]=[CH:9][C:4]=2[N:3]1[CH:11]1[CH2:16][CH2:15][N:14](C(OCC2C=CC=CC=2)=O)[CH2:13][CH2:12]1>CCO.[Pd]>[NH:14]1[CH2:15][CH2:16][CH:11]([N:3]2[C:4]3[CH:9]=[CH:8][N:7]=[N:6][C:5]=3[NH:10][C:2]2=[O:1])[CH2:12][CH2:13]1

Komponenten

4

Edukt 1

HCID 22293218benzyl 4-(6-oxo-6,7-dihydro-5H-imidazo[4,5-c]pyridazin-5-yl)piperidine-1-carboxylate

Produkt 1

HCID 222933035-Piperidin-4-yl-5,7-dihydro-6H-imidazo[4,5-c]pyridazin-6-oneAusbeute 119,8 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of benzyl 4-(6-oxo-6,7-dihydro-5H-imidazo[4,5-c]pyridazin-5-yl)piperidine-1-carboxylate (35 mg, 0.099 mmol) and 10% Pd/C (50 mg) in EtOH (5 mL), was hydrogenated under a balloon overnight. The reaction was filtered through Celite with more EtOH and concentrated to afford the title compound (26 mg). MS 220.2 (M+1).

Aufarbeitung

  1. customwas hydrogenated under a balloon overnight
  2. filtrationThe reaction was filtered through Celite with more EtOH
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-427739c7ef3f4e1abb3c5076b185dc70
Quelldatensatz
uspto-grants-2007_06
Patentnummer
US07235545B2

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