Trifluoroacetic acid → Trifluoroacetic acid

HRID 1768257Notes

Reaction equation

HRID 1768257 reaction equation
C(OC([N:8]([C@@H:16]1[CH2:22][CH2:21][C@@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:24]=2[F:30])[CH:19]([CH2:31][OH:32])[NH:18][C:17]1=[O:33])C(OC(C)(C)C)=O)=O)(C)(C)C.[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35]>C(Cl)Cl>[NH2:8][C@@H:16]1[CH2:22][CH2:21][C@@H:20]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([F:29])[C:24]=2[F:30])[CH:19]([CH2:31][OH:32])[NH:18][C:17]1=[O:33].[C:34]([OH:40])([C:36]([F:39])([F:38])[F:37])=[O:35]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 21114343HCID 21114343, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 66939139HCID 66939139, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Di-tert-butyl[(3R,6S)-6-(2,3-difluorophenyl)-7-(hydroxymethyl)-2-oxoazepan-3-yl]imidodicarbonate (100 mg, 0.213 mmol) was diluted DCM (30 mL) and TFA (8 mL) was added. After 2 h, the reaction was concentrated to give the title compound as its TFA salt (57 mg). MS 271.0 (M+1).

Workup

  1. additionwas added
  2. concentrationthe reaction was concentrated

Sources & evidence

ORD record
ord-9c55b4aedad54ba0ae86faf171c8453b
Source dataset
uspto-grants-2007_06
Patent number
US07235545B2

Reaction notes

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