1H-indol-4-ol → HCID 69507256, compound

HRID 1768429Notes

Reaction equation

HRID 1768429 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[CH:5][NH:6]2.C([O:13][C:14](=O)[C:15]([C:27]#[N:28])=[CH:16][C:17]1[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=1[O:25][CH3:26])C>>[C:27]([CH:15]1[C:16]([C:17]2[CH:22]=[C:21]([O:23][CH3:24])[CH:20]=[CH:19][C:18]=2[O:25][CH3:26])=[C:10]2[C:2](=[C:3]3[CH:4]=[CH:5][N:6]=[C:7]3[CH:8]=[CH:9]2)[O:1][C:14]1=[O:13])#[N:28]

Participants

3

Reactant 2

HCID 754211H-indol-4-olHCID 29737180777-94-2

Product 1

HCID 69507256HCID 69507256, compoundYield 2.6%

Procedure

The title compound was prepared from 4-hydroxyindole and 3-(2,5-dimethoxyphenyl)-2-cyano-acrylic acid ethyl ester by a procedure similar to that described for Example 16 in 2.6% yield. 1H NMR (CDCl3): 8.64 (s, 1H), 7.33-7.31 (m, 1H), 7.29-7.24 (m, 1H), 7.10-7.01 (m, 4H), 6.83-6.82 (m, 1H), 3.82 (s, 3H), 3.77 (s, 3H).

Sources & evidence

ORD record
ord-d6afd0324cfa4962bf2bd42287974aaf
Source dataset
uspto-grants-2007_06
Patent number
US07235674B2

Reaction notes

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