Sodium Hydroxide → Theophylline

HRID 1768485Notes

Reaction equation

HRID 1768485 reaction equation
[OH-:1].[Na+].C1N=C(N)[C:6]2[N:11]=[CH:10][N:9]([C@@H:12]3O[C@H](COP(OP(OC[C@H]4O[C@@H](N5C=C(C(N)=O)CC=C5)[C@H](O)[C@@H]4O)(O)=O)(O)=O)[C@@H](O)[C@H]3O)[C:7]=2[N:8]=1.[N-]=[N+]=[N-].[Na+].[CH2:51]([NH:55][CH2:56]O)[C:52]([O-])=[O:53].[Na+]>O>[N:11]1([C:52](=[O:53])[C:51]2[NH:55][CH:56]=[N:8][C:7]=2[N:9]([CH3:12])[C:10]1=[O:1])[CH3:6]

Participants

6

Reactant 4

HCID 14798Sodium HydroxideHCID 33557Sodium AzideHCID 439153NadhHCID 23664641Sodium N-(hydroxymethyl)glycinate

Product 1

HCID 2153Theophylline

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

One liter of a first reagent was prepared as follows. Approximately 800 ml deionized water was dispensed into a container and 6.0 grams of ACES were added and dissolved. The pH was adjusted to 6.0 with 2 N NaOH. Then 0.66 grams NAD were added and dissolved completely. Then 0.95 grams sodium azide was added and dissolved, and finally 1.0 gram of SUTTOCIDE A was added and dissolved. The volume was adjusted to one liter with deionized water.

Workup

  1. additionwere added
  2. dissolutiondissolved
  3. dissolutiondissolved completely
  4. dissolutiondissolved
  5. dissolutiondissolved

Sources & evidence

ORD record
ord-5a24a8b778c649a68f55a776f0bc1d08
Source dataset
uspto-grants-2007_06
Patent number
US07235675B2

Reaction notes

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