6-Cyano-1-hydroxy-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene → 6-Cyano-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

HRID 1768638Notes

Reaction equation

HRID 1768638 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](O)([C:13]1[S:17][N:16]=[CH:15][CH:14]=1)[CH2:8][CH2:7][CH2:6]2)#[N:2]>C(O)(=O)C>[C:1]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]([C:13]1[S:17][N:16]=[CH:15][CH:14]=1)[CH2:8][CH2:7][CH2:6]2)#[N:2]

Participants

3

Reactant 1

HCID 189490166-Cyano-1-hydroxy-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

Product 1

HCID 189490196-Cyano-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Analogously to Example 4, 6-cyano-1-hydroxy-1-(5-isothiazolyl)-1,2,3,4-tetrahydronaphthalene (Example 15) in glacial acetic acid is convened into the title compound using tin(II) chloride and 36.5% hydrochloric acid.

Sources & evidence

ORD record
ord-3eb42e04ac354378978dfb8b47ed658e
Source dataset
uspto-grants-1995_01
Patent number
US05378721

Reaction notes

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